What is the incidence of cancer among the general USA population?

My husband is from a big family, and three people in his family have died, or are dying, of cancer in the last few years: a brother, a sister, and a brother-in-law. His siblings and spouses are aged 45 to 70, and there are 20 of us. How does this compare to the percentage of the general population? Would you say cancer is prevalent in his family?